FreeXamine

sleep

Compounds that promote restful and uninterrupted sleep

Proven supplements for sleep wellness

Magnesium
Improves sleep quality and reduces insomnia symptoms (20–25% improvement in sleep efficiency); supports GABA activity and muscle relaxation,
Valerian
Valerian is a natural herb that promotes relaxation, reduces stress and anxiety, and improves the quality of sleep by regulating the body's sleep-wake cycle, making it easier to fall asleep and stay asleep.
Melatonin
Melatonin helps regulate sleep-wake cycles by binding to melatonin receptors in the brain, inducing drowsiness, reducing sleep latency, and increasing sleep duration, particularly beneficial for insomnia, jet lag, and shift work sleep disorders.
L-Theanine
Promotes relaxation and reduces stress. Improves sleep quality in mild insomnia or stress-related sleep issues.
Lavender
Lavender promotes relaxation, reduces anxiety, and calms the mind, making it easier to fall asleep and improve sleep quality.
Rhodiola
Rhodiola helps regulate sleep patterns by reducing stress and anxiety, promoting a restful night's sleep, and improving overall sleep quality due to its adaptogenic properties.
Ashwagandha
Ashwagandha helps regulate sleep patterns by reducing stress and anxiety, promoting relaxation, and improving the quality of sleep, leading to better rest and recovery.
5-HTP
5-HTP (5-Hydroxytryptophan) is an amino acid that the body uses to produce serotonin, a neurotransmitter that regulates sleep, mood, and appetite. Taking 5-HTP supplements may increase serotonin levels, promoting relaxation, reducing anxiety, and improving sleep quality.

Best sleep Combinations for Maximum Benefits

  • Enhanced mood regulation and antidepressant effectsHyperforin increases levels of serotonin, dopamine, and norepinephrine in the brain, which are key neurotransmitters involved in mood regulation.
  • Improved treatment consistency and effectivenessSt.
  • Potential anti-inflammatory and neuroprotective propertiesBeyond mood support, St.
  • Enhances deep sleep quality significantly.
  • Relieves muscle tension and cramps effectively.
  • Supports nervous system calm and resilience.
  • Enhances sleep quality and shortens sleep onset.
  • Reduces stress and anxiety without sedation.
  • Improves cognitive performance under pressure.
  • Reduces time to fall asleep significantly.
  • Improves overall sleep quality and depth.
  • Supports relaxation without next-day drowsiness.
  • Enhanced sleep quality and faster sleep onsetGlycine lowers core body temperature and modulates neurotransmitters to promote sleep, while Lavender reduces anxiety that may delay sleep initiation.
  • Reduced anxiety and stress levelsLavender’s flavonoids enhance GABA activity, promoting calmness, while Glycine’s anti-inflammatory and neurotransmitter-regulating effects may mitigate stress-related physiological responses, creating additive anxiolytic benefits.
  • Improved relaxation without daytime drowsinessLavender’s mild sedative properties complement Glycine’s role in neurotransmitter balance, supporting relaxation at night while maintaining alertness during the day due to differing receptor targets.
  • Enhanced sleep quality through complementary mechanismsGlycine promotes sleep by binding to NMDA receptors and lowering body temperature, while organic cherry provides melatonin to regulate circadian rhythms.
  • Reduced inflammation via dual antioxidant pathwaysGlycine inhibits pro-inflammatory cytokines and supports glutathione production, whereas cherry's anthocyanins scavenge free radicals.
  • Improved metabolic and cardiovascular health markersGlycine enhances insulin sensitivity and reduces fat accumulation, while cherry's polyphenols improve endothelial function.
  • Enhanced sleep quality through combined sedative and anxiolytic effectsThe combination of Valerian's sedative properties and Lavender's anxiolytic effects may work synergistically to improve sleep quality by addressing both the ability to fall asleep and stay asleep.
  • Improved stress management through complementary mechanisms of actionValerian and Lavender target different aspects of stress response.
  • Potential reduction in anxiety symptoms without significant sedationLavender's anxiolytic effects, potentially enhanced by Valerian's calming influence, may help reduce anxiety symptoms.
  • Improved sleep onset and durationValerian enhances GABA activity, promoting relaxation and deeper sleep, while cherry provides melatonin, which helps regulate the timing of sleep.
  • Reduced anxiety and stress levelsValerian has anxiolytic effects through its influence on GABA receptors, and cherry's antioxidants may reduce oxidative stress, which is often elevated in stress-related conditions, thereby complementing each other in stress reduction.
  • Enhanced sleep quality and efficiencyCherry's melatonin supports circadian rhythm alignment, while Valerian increases sleep depth and reduces nighttime awakenings, leading to more restorative and uninterrupted sleep when used together.
  • Enhanced sleep quality and faster sleep onsetValerian increases GABA availability, while apigenin enhances GABA-A receptor activity, leading to a synergistic calming effect that improves sleep initiation and maintenance.
  • Reduced anxiety and nervous system overactivityBoth compounds modulate GABA signaling, with apigenin acting on benzodiazepine receptor sites and Valerian increasing GABA levels, resulting in additive anxiolytic effects without significant cognitive impairment.
  • Natural, non-addictive relaxation supportUnlike benzodiazepines or barbiturates, Valerian and apigenin offer a gentler, non-habit-forming way to support nervous system balance, making them suitable for long-term use in many cases.
  • Enhanced sleep quality and durationThe combination of Valerian and Glycine may lead to improved sleep outcomes due to their synergistic effects on the GABAergic system and inhibitory neurotransmission.
  • Increased relaxation and reduced anxietyValerian's modulation of the GABAergic system, combined with Glycine's inhibitory neurotransmission, can promote a state of relaxation and reduce anxiety levels.
  • Potential improvement in sleep disordersThe synergistic effects of Valerian and Glycine may help alleviate sleep disorders by promoting a more restful and prolonged sleep.