FreeXamine

anti-aging

Delay the signs of aging and support cellular vitality

Most effective anti-aging supplements

Curcumin
Curcumin, derived from turmeric, reduces systemic inflammation, supports brain function, and activates AMPK and autophagy pathways, contributing to healthier aging. Bioavailable forms like Longvida or Meriva enhance its effectiveness.
Berberine
Berberine activates AMPK, a key longevity enzyme, improving glucose regulation and lipid metabolism. It mimics the anti-aging effects of metformin and supports mitochondrial health.
Quercetin
Quercetin acts as a senolytic compound, helping clear damaged senescent cells that accumulate with age. It also has strong antioxidant and anti-inflammatory effects.
Nicotinamide Mononucleotide (NMN)
NMN boosts NAD⁺ levels, which decline with age, supporting mitochondrial energy production, DNA repair, and sirtuin activation. Studies show it improves metabolism and cellular resilience, making it one of the most promising longevity compounds.
Nicotinamide Riboside (NR)
NR is a clinically tested NAD⁺ precursor that enhances cellular energy and mitochondrial function. It mimics calorie restriction effects, improves insulin sensitivity, and supports DNA repair mechanisms.
Coenzyme Q10
CoQ10, especially in its active form ubiquinol, is essential for mitochondrial energy production and acts as a powerful antioxidant, protecting cells from oxidative damage and improving cardiovascular health.
Sulforaphane Glucosinolate (SGS)
Sulforaphane activates the NRF2 pathway, enhancing the body’s natural antioxidant defense and detoxification systems. It helps protect cells from oxidative and environmental stressors linked to aging.
Astaxanthin
Astaxanthin is a potent carotenoid antioxidant that protects cell membranes and mitochondria from oxidative damage, enhances skin elasticity, and reduces inflammation associated with aging

Best anti-aging Combinations for Maximum Benefits

  • Enhanced mitochondrial function and energy productionPQQ stimulates mitochondrial biogenesis, increasing the number of mitochondria in cells, while omega-3 fatty acids improve mitochondrial membrane integrity and efficiency.
  • Improved cognitive performance and neuroprotectionDHA from fish oil is a critical structural component of brain cell membranes, supporting synaptic function, while PQQ protects neurons from oxidative stress, promotes nerve growth factor synthesis, and supports memory and learning.
  • Reduced systemic inflammation and oxidative stressOmega-3s are converted into resolvins and protectins that actively resolve chronic inflammation, while PQQ acts as a potent antioxidant that neutralizes free radicals and upregulates endogenous antioxidant systems like glutathione.
  • Enhanced mitochondrial function and cellular energy productionUrolithin A activates mitophagy, clearing dysfunctional mitochondria, while Omega-3 fatty acids support mitochondrial membrane stability and efficiency.
  • Reduced systemic inflammation and improved tissue recoveryOmega-3s lower pro-inflammatory eicosanoids and cytokines, while Urolithin A suppresses NF-κB signaling and inflammasome activation.
  • Support for muscle health and physical enduranceClinical studies show Urolithin A improves muscle strength and endurance in older adults by enhancing mitochondrial turnover.
  • Enhanced antioxidant and anti-inflammatory protectionSGS activates the Nrf2 pathway, increasing antioxidant production, while omega-3s reduce inflammation through eicosanoid modulation.
  • Improved cardiovascular healthOmega-3s support heart health by lowering triglycerides and improving lipid profiles, while sulforaphane promotes vascular function and reduces oxidative damage, both contributing to a healthier cardiovascular system.
  • Support for brain health and cognitive functionOmega-3 fatty acids are essential for brain structure and function, and sulforaphane's neuroprotective properties through antioxidant pathways may enhance cognitive resilience and reduce neuroinflammation.
  • Enhanced cellular protection against oxidative stressSGS activates the Nrf2 pathway, which increases production of antioxidant enzymes like glutathione and superoxide dismutase.
  • Improved mitochondrial function and longevityUrolithin A promotes mitophagy, helping remove damaged mitochondria and maintain efficient energy production.
  • Supports healthy aging and metabolic functionBoth compounds have been studied for their roles in promoting longevity pathways—SGS through detoxification and antioxidant systems, and Urolithin A through mitochondrial health and inflammation regulation.
  • Enhanced mitochondrial function and cellular energy productionPQQ stimulates mitochondrial biogenesis, which increases the number and efficiency of mitochondria.
  • Reduced oxidative stress and inflammationBoth PQQ and fisetin have antioxidant properties.
  • Improved cognitive and neuroprotective healthPQQ supports nerve growth factor (NGF) and neuronal survival, while fisetin has been shown to enhance memory and protect neurons through anti-inflammatory and senolytic actions.
  • Enhanced mitochondrial turnover and functionPQQ stimulates the creation of new mitochondria through activation of PGC-1α and related pathways, increasing cellular energy capacity.
  • Improved muscle endurance and strengthClinical studies show Urolithin A improves muscle strength and endurance in older adults by enhancing mitochondrial efficiency in muscle cells.
  • Support for brain health and cognitive functionPQQ has been shown to protect neurons from oxidative stress and support nerve growth factor synthesis, promoting neuroplasticity and cognitive resilience.
  • Enhanced antioxidant defenses through direct and indirect pathwaysPQQ directly scavenges free radicals, while SGS induces the expression of antioxidant genes through the Nrf2 pathway, providing a comprehensive antioxidant effect.
  • Improved mitochondrial function and biogenesisPQQ promotes mitochondrial biogenesis, and sulforaphane (from SGS) protects mitochondria from oxidative damage, potentially leading to enhanced cellular energy metabolism.
  • Potential neuroprotective effects through reduced oxidative stressThe combination of PQQ and SGS may offer neuroprotection by both directly reducing oxidative stress and inducing cellular protective mechanisms.
  • Enhanced mitochondrial function and biogenesisPQQ is known to enhance mitochondrial biogenesis and function.
  • Increased antioxidant capacityThe combination of PQQ and Quercetin may provide a broader antioxidant coverage due to their different mechanisms of action, potentially leading to enhanced protection against oxidative damage.
  • Potential anti-inflammatory effectsQuercetin has known anti-inflammatory properties.
  • Increased NAD+ levels through complementary mechanisms.
  • Enhanced cellular energy metabolism and mitochondrial function.
  • Potential support for cellular health and longevity pathways.
  • Enhanced cellular energy production and mitochondrial functionNR increases NAD+ levels, which fuels mitochondrial activity, while Resveratrol activates sirtuins that promote mitochondrial biogenesis.
  • Improved DNA repair and cellular longevityHigher NAD+ from NR boosts the activity of PARP1, a key DNA repair enzyme.
  • Support for healthy aging and metabolic functionResveratrol mimics calorie restriction effects by activating longevity pathways, and NR supports these processes by maintaining NAD+ levels that typically decline with age, promoting metabolic and cellular health.