Yohimbine
Yohimbine is an alkaloid derived from the bark of the Pausinystalia johimbe tree and has been used for various purposes including as an aphrodisiac and for weight loss. It acts as an alpha-2 adrenergic receptor antagonist.
Effectiveness and Risk Overview
Condition | Effectiveness | Details |
|---|---|---|
| Erectile Dysfunction | Yohimbine has been shown to be effective in treating erectile dysfunction, particularly in cases with psychogenic origins. Clinical trials and meta-analyses support its efficacy, although results can vary. | |
| Low Libido | Some studies suggest that yohimbine can improve libido, though the evidence is not as strong as for erectile dysfunction. It is believed to work by increasing blood flow and enhancing sexual arousal. | |
| Weight Loss | Yohimbine is sometimes used as a weight loss supplement due to its potential to increase fat burning. However, evidence is mixed, and results can vary significantly between individuals. | |
| Fatigue | Yohimbine may help reduce fatigue due to its stimulant properties. However, the evidence is not conclusive, and individual results may vary. | |
| Athletic Performance | There is some evidence suggesting yohimbine may enhance athletic performance by increasing fat loss and potentially improving exercise performance. However, more research is needed to confirm its effectiveness. | |
| Causes anxiety and panic attacks. | Yohimbine can cause significant anxiety and panic attacks in some individuals due to its stimulatory effects on the nervous system. This is particularly concerning for people with a history of anxiety disorders. | |
| Increases blood pressure significantly. | As a stimulant, yohimbine can increase blood pressure, which may be problematic for individuals with pre-existing hypertension or cardiovascular conditions. | |
| May cause interactions with MAOIs. | Yohimbine can interact with monoamine oxidase inhibitors (MAOIs), potentially leading to dangerous levels of certain neurotransmitters in the body, such as serotonin and norepinephrine, which can cause serious health issues. |
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