Great Synergy!

Can you take 5-MTHF L-Methylfolate and Spinach Extract together?

Interaction Details

Taking 5-MTHF L-Methylfolate and Spinach Extract together has the potential for good synergy, suggesting a rating of 4 out of 5.

The synergy between 5-MTHF L-Methylfolate and Spinach Extract can be attributed to their complementary roles in supporting folate metabolism and antioxidant defenses. 5-MTHF is the active form of folate, crucial for DNA synthesis, repair, and methylation, while Spinach Extract is rich in antioxidants like lutein and zeaxanthin, which protect cells from oxidative stress. Spinach is also a rich source of folate, which can complement the action of 5-MTHF. The combination may enhance the bioavailability and utilization of folate, while the antioxidants in Spinach Extract may help mitigate oxidative stress that can be a byproduct of increased folate metabolism. This combined effect may lead to enhanced overall health benefits, including improved cellular function and antioxidant status.

Potential Benefits

Improves detoxification process.

The combination of 5-MTHF L-Methylfolate and Spinach Extract supports the body's natural detoxification process by enhancing the expression of genes involved in glutathione synthesis, a crucial antioxidant for removing toxins from the body.

Enhances cognitive function.

The synergy between 5-MTHF L-Methylfolate and Spinach Extract promotes the production of neurotransmitters, such as serotonin and dopamine, which are essential for regulating mood, appetite, and sleep, leading to improved cognitive function and mental clarity.

Supports eye health.

The combination of 5-MTHF L-Methylfolate and Spinach Extract provides a boost to the levels of lutein and zeaxanthin, carotenoids present in spinach, which are known to protect the macula and reduce the risk of age-related macular degeneration.

Potential Risks

Exacerbates kidney stones.

The increased levels of folate from 5-MTHF L-Methylfolate, combined with the high oxalate content in spinach extract, may increase the risk of developing kidney stones, particularly in individuals with a history of kidney stone issues.

Worsens thyroid issues.

The combination of 5-MTHF L-Methylfolate and Spinach Extract may interfere with thyroid function, particularly in individuals with hypothyroidism, as the high levels of folate may inhibit the absorption of thyroid hormones.

Recommended Supplement for mood

5-MTHF L-Methylfolate

5-MTHF L-Methylfolate (also sometimes called Levomefolate) is the active form of folate – also known as vitamin B9. It's used by the body to perform a variety of critical functions, including synthesizing DNA, repairing and methylating DNA, and serving as a cofactor in biological reactions, particularly in the nervous system.

Spinach Extract

Spinach Extract is a dietary supplement derived from spinach leaves, often used for its potential health benefits.

Some benefits of Spinach Extract include: